Stuart has not played since dislocating his elbow in the climax to the autumn against South Africa and his most recent club outing was against Saracens in October, upon which he faced another spell out because of knee damage.
If Sinckler’s wound fails to heal sufficiently, Cole and Stuart will battle it out for the number three jersey against Warren Gatland’s men.
Courtney Lawes will also receive treatment in the camp that fills the first break week in the hope of facing Wales having struggled with a calf injury that has prevented him from taking part in the Six Nations to date.
Sale flanker Ben Curry is present despite being dropped against Italy, but there is no place for his twin brother Tom who is nearing recovery from a hamstring issue.
In a sign of Manu Tuilagi’s slide down the pecking order he has been left out of the 26 altogether with Henry Slade, Ollie Lawrence and Joe Marchant the specialist centres named by Borthwick.
England U20s players will join their senior counterparts to boost the numbers for training sessions.
England training squad:
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Forwards: O Chessum (Leicester Tigers), D Cole (Leicester Tigers), B Curry (Sale Sharks), A Dombrandt (Harlequins), B Earl (Saracens), E Genge (Bristol Bears), J George (Saracens), N Isiekwe (Saracens), M Itoje (Saracens), L Ludlam (Northampton Saints), W Stuart (Bath Rugby), M Vunipola (Saracens), J Walker (Harlequins), J Willis (Toulouse).
Backs: H Arundell (London Irish), O Farrell (Saracens), O Hassell-Collins (London Irish), O Lawrence (Bath Rugby), M Malins (Saracens), J Marchant (Harlequins), A Mitchell (Northampton Saints), H Slade (Exeter Chiefs), M Smith (Harlequins), F Steward (Leicester Tigers), J van Poortvliet (Leicester Tigers), A Watson (Leicester Tigers).
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