MADELEINE McCann's siblings were just two years old when she disappeared from the family's holiday apartment in Portugal in 2007.
Now fifteen years on, they are teenagers and have spent most of their lives without knowing their big sister.
Who are Madeleine McCann's siblings?
Sean and Amelie McCann were just two years old at the time of Madeleine McCann's disappearance on May 3, 2007.
from her bed in the family's holiday apartment in Portugal.
They were sleeping next to Madeleine's bed seemingly undisturbed during the break in, though there has been some suggestion that the pair had been sedated this has never been proven.
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Have Kate and Gerry McCann had any more children?
Madeleine, would be 19 years old now, and her parents Kate and Gerry McCann have not had anymore children since her disappearance in 2007.
The couple have been relentless in their efforts to find her.
In the 15 years since her disappearance, a convicted child abuser named as Christian B was made an official suspect.
On May 3, her parents joined friends and well wishers in an event to remember Madeleine on the 15th anniversary of her disappearance.
They didn't address the crowd of around 100 people, but the anguished mum read a poem saying: “Survival can be summed by up three words"
“Never give up.
“That’s the heart of it really, just keep trying.
"Sometimes you have to get knocked down, Lower than you have ever been.
“To stand up taller than you ever were.
“Perseverance is stubbornness.”
Kate previously worked as a GP and is now a medical worker, she told The Sun:
“I just want to know if she’s alive or dead. Not knowing is the worst thing — a never-ending torture. Anyone with a missing child will tell you that.”
Speaking in the past to promote her charity Missing People of which she is an ambassador, she said: “We miss our complete family of five.
“As a family 98 per cent of the time we’re busy. I don’t know if that’s a conscious thing but it helps.
"The urge to look for Madeleine absolutely hasn’t changed at all.”
Where are Madeleine McCann's brother and sister now?
Twins Sean and Amelie, now 17 live in their home in the town of Loughborough in Leicestershire with parents Kate and Gerry.
They attend a Catholic secondary school in the area which still remembers their older sister as she also attended the school.
According to their mum Kate, they are both aspiring athletes and have competed in triathlons and country crossing racing.
For their own privacy and safety, there are no photographs as teenagers that are available to the public.
Their missing sister remains a cloud over the entire McCann family.
They were found sleeping peacefully when it was discovered that Maddie had disappeared from her bed.
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